Department of Medicine and Surgery Sciences, University of Bologna, Bologna, Italy; and Italian Society of Nutraceuticals.
Clinic of Cardiology, University Clinical Centre of Kosovo, Prishtina, Kosovo; Medical Faculty, University of Prishtina, Prishtina, Kosovo; and Kosovo Society of Cardiology.
Nutr Rev. 2017 Sep 1;75(9):731-767. doi: 10.1093/nutrit/nux047.
In recent years, there has been growing interest in the possible use of nutraceuticals to improve and optimize dyslipidemia control and therapy. Based on the data from available studies, nutraceuticals might help patients obtain theraputic lipid goals and reduce cardiovascular residual risk. Some nutraceuticals have essential lipid-lowering properties confirmed in studies; some might also have possible positive effects on nonlipid cardiovascular risk factors and have been shown to improve early markers of vascular health such as endothelial function and pulse wave velocity. However, the clinical evidence supporting the use of a single lipid-lowering nutraceutical or a combination of them is largely variable and, for many of the nutraceuticals, the evidence is very limited and, therefore, often debatable. The purpose of this position paper is to provide consensus-based recommendations for the optimal use of lipid-lowering nutraceuticals to manage dyslipidemia in patients who are still not on statin therapy, patients who are on statin or combination therapy but have not achieved lipid goals, and patients with statin intolerance. This statement is intended for physicians and other healthcare professionals engaged in the diagnosis and management of patients with lipid disorders, especially in the primary care setting.
近年来，人们对营养保健品在改善和优化血脂异常控制和治疗方面的潜在应用越来越感兴趣。基于现有研究的数据，营养保健品可能有助于患者实现治疗性的血脂目标，并降低心血管残余风险。一些营养保健品具有在研究中得到证实的基本降脂特性；一些营养保健品也可能对非脂心血管危险因素有积极影响，并已被证明可改善血管健康的早期标志物，如内皮功能和脉搏波速度。然而，支持使用单一降脂营养保健品或其组合的临床证据在很大程度上是可变的，而且对于许多营养保健品，证据非常有限，因此往往存在争议。本立场文件的目的是提供基于共识的建议，以优化降脂营养保健品的使用，管理尚未接受他汀类药物治疗的患者、已接受他汀类药物或联合治疗但未达到血脂目标的患者以及他汀类药物不耐受的患者的血脂异常。本声明适用于参与诊断和管理血脂异常患者的医生和其他医疗保健专业人员，特别是在初级保健环境中。
