一种新的 CTGF 靶点在肾纤维化中的作用。
A new CTGF target in renal fibrosis.
机构信息
Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA; Renal Section, Denver Veterans Affairs Medical Center, Denver, Colorado, USA.
Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA; Department of Medicine, Denver Health Hospital, Denver, Colorado, USA; Consortium for Fibrosis Research and Translation, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA.
出版信息
Kidney Int. 2017 Oct;92(4):784-786. doi: 10.1016/j.kint.2017.04.042.
Lymphangiogenesis appears to accompany renal fibrosis, but signals that regulate the lymphangiogenic growth factor vascular endothelial growth factor C are not well understood. Kinashi et al. have shown that conditionally deleting connective tissue growth factor reduces renal fibrosis, vascular endothelial growth factor C, and lymphangiogenesis. Connective tissue growth factor has pleiotropic effects in the setting of renal fibrosis; this study adds a potentially new mechanism for the profibrotic effects of connective tissue growth factor.
淋巴管生成似乎伴随着肾纤维化，但调节淋巴管生成生长因子血管内皮生长因子 C 的信号尚未得到很好的理解。Kinashi 等人已经表明，条件性删除结缔组织生长因子可减少肾纤维化、血管内皮生长因子 C 和淋巴管生成。结缔组织生长因子在肾纤维化中具有多种作用；这项研究为结缔组织生长因子的促纤维化作用增加了一个潜在的新机制。
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