Epstein R J
University Department of Clinical Oncology and Radiotherapeutics, Addenbrooke's Hospital, Cambridge.
Lancet. 1988 Mar 5;1(8584):521-4. doi: 10.1016/s0140-6736(88)91308-6.
Topoisomerases are DNA-modifying enzymes that are becoming increasingly important in clinical practice. These enzymes form a target for antibiotics, autoantibodies, and antitumour drugs, and may also be involved in the pathogenesis of certain genetic disorders. Strategies for clinical manipulation of these nuclear enzyme targets are discussed.
拓扑异构酶是一类DNA修饰酶，在临床实践中变得越来越重要。这些酶成为抗生素、自身抗体和抗肿瘤药物的作用靶点，并且可能还参与某些遗传疾病的发病机制。本文讨论了针对这些核酶靶点进行临床操作的策略。
