Topoisomerases in human disease.
作者信息
Epstein R J
机构信息
University Department of Clinical Oncology and Radiotherapeutics, Addenbrooke's Hospital, Cambridge.
出版信息
Lancet. 1988 Mar 5;1(8584):521-4. doi: 10.1016/s0140-6736(88)91308-6.
PMID:2893929
Abstract
Topoisomerases are DNA-modifying enzymes that are becoming increasingly important in clinical practice. These enzymes form a target for antibiotics, autoantibodies, and antitumour drugs, and may also be involved in the pathogenesis of certain genetic disorders. Strategies for clinical manipulation of these nuclear enzyme targets are discussed.
摘要
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