Kato Takeharu, Miyoshi Hiroaki, Kobayashi Seiichiro, Yoshida Noriaki, Imaizumi Yoshitaka, Seto Masao, Uchimaru Kaoru, Miyazaki Yasushi, Ohshima Koichi
Department of Pathology, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.
Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Virchows Arch. 2017 Nov;471(5):659-666. doi: 10.1007/s00428-017-2233-9. Epub 2017 Sep 22.
Peripheral T cell lymphoma, not otherwise specified (PTCL-NOS), is a heterogeneous disease with respect to clinicopathological features. Cell adhesion molecule 1 (CADM1) has been reported to be ectopically expressed in adult T cell leukaemia/lymphoma (ATLL). However, the frequency of CADM1 expression remains unknown in peripheral T cell lymphomas. In the current study, CADM1 expression was analysed in 88 PTCL-NOS patients. CADM1 was expressed in 14 of 88 (15.9%) PTCL-NOS cases, and its expression was associated with C-C chemokine receptor type 4 (CCR4) expression and nuclear atypia. CADM1-positive PTCL-NOS cases (10/74) had a significantly poorer prognosis than CADM1-negative cases (64/74) (P = 0.001). Multivariate analysis confirmed that CADM1 expression was an independent prognostic factor in PTCL-NOS. These findings suggest that CADM1 expression is a novel prognostic factor for PTCL-NOS.
外周T细胞淋巴瘤，非特殊类型（PTCL-NOS）在临床病理特征方面是一种异质性疾病。据报道，细胞粘附分子1（CADM1）在成人T细胞白血病/淋巴瘤（ATLL）中异位表达。然而，CADM1在外周T细胞淋巴瘤中的表达频率尚不清楚。在本研究中，分析了88例PTCL-NOS患者的CADM1表达情况。88例PTCL-NOS病例中有14例（15.9%）表达CADM1，其表达与C-C趋化因子受体4（CCR4）表达及核异型性相关。CADM1阳性的PTCL-NOS病例（10/74）的预后明显比CADM1阴性病例（64/74）差（P = 0.001）。多因素分析证实，CADM1表达是PTCL-NOS的一个独立预后因素。这些发现表明，CADM1表达是PTCL-NOS的一个新的预后因素。
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