Karam M, Schulz-Key H, Remme J
Onchocerciasis Control Programme, Ouagadougou, Burkina Faso.
Acta Trop. 1987 Dec;44(4):445-57.
In an attempt to describe the changing population dynamics of Onchocerca volvulus during a period of vector control, nodulectomies were undertaken in 256 patients from ten villages in the Onchocerciasis Control Programme (OCP) and in 74 patients from two villages in an area with ongoing transmission. A total of 1198 nodules were excised and 4350 adult worms were isolated and examined for viability and productivity. In the OCP villages, the worm population is ageing and dying without replacement by new generations of parasites and various findings signal a breakdown of the worm population after about 12 years interruption of transmission. The sexual activity of the worms was significantly reduced. A Productivity Index was developed to measure the microfilariae production at the nodule level. The reduction in this index for the OCP villages correlates closely with the decline over the control period in the community microfilarial loads in the skin. The results show that it is not only the longevity of the parasite which will determine the duration of vector control, but that the reduced productivity of the ageing parasite population is of equal importance.
为了描述盘尾丝虫病控制项目（OCP）期间盘尾丝虫种群动态的变化，对来自OCP十个村庄的256名患者以及来自疾病正在传播地区两个村庄的74名患者进行了结节切除术。总共切除了1198个结节，分离出4350条成虫，并检查其活力和繁殖力。在OCP村庄，虫口正在老化和死亡，没有新一代寄生虫的替代，各种研究结果表明，在大约12年的传播中断后，虫口出现了崩溃。蠕虫的性活动显著减少。开发了一个繁殖力指数来衡量结节水平的微丝蚴产生情况。OCP村庄该指数的下降与对照期内社区皮肤微丝蚴负荷的下降密切相关。结果表明，不仅寄生虫的寿命决定了病媒控制的持续时间，而且老化寄生虫种群繁殖力的下降同样重要。
