Ouma John R, Modikeng Lebohang C, Mohanlal Reena
Department of Neurological Surgery, University of the Witwatersrand, Johannesburg, and Chris Hani Baragwanath Academic Hospital, Soweto, South Africa.
Department of Neurological Surgery, University of the Witwatersrand, Johannesburg, and Chris Hani Baragwanath Academic Hospital, Soweto, South Africa.
World Neurosurg. 2017 Dec;108:997.e5-997.e7. doi: 10.1016/j.wneu.2017.09.068. Epub 2017 Sep 21.
The clivus is a rare site of tumor occurrence in general, and metastases to this site are especially rare. Renal cell carcinoma is an uncommon entity in the pediatric population. Although not infrequent in adults, when it does occur, metastases to the clivus are extremely uncommon, only having been reported 3 times in the literature. All of these cases involved adults in their sixth decade.
We present the first report in the literature of renal cell carcinoma occurring in a pediatric patient and spreading to the clivus. This 11-year-old girl presented with headaches and diplopia based on a left-sided sixth cranial nerve palsy, in the context of a wasting disease. She was also found to have vague abdominal fullness, although it was only after biopsy of a clivus lesion identified on brain scanning that its true nature became apparent, prompting abdominal scans, which revealed a renal mass with hepatic metastases.
This article reports for the first time in the literature the spread of a translocation renal cell carcinoma to the clivus in a young child. This serves to alert practitioners to this possibility when faced with a similar scenario.
一般来说，斜坡是肿瘤发生的罕见部位，转移至该部位的情况尤其罕见。肾细胞癌在儿科人群中并不常见。虽然在成人中并不罕见，但一旦发生，转移至斜坡极为罕见，文献中仅报道过3例。所有这些病例均为60岁左右的成年人。
我们报告了文献中首例发生于儿科患者并转移至斜坡的肾细胞癌。这名11岁女孩因左侧展神经麻痹出现头痛和复视，同时患有消耗性疾病。她还被发现有腹部胀满感，但直到脑部扫描发现斜坡病变活检后其真实性质才显现出来，随后进行的腹部扫描显示有一个肾肿块伴肝转移。
本文首次在文献中报道了一名幼儿的易位性肾细胞癌转移至斜坡的情况。这提醒从业者在面对类似情况时要注意这种可能性。
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