肌球蛋白18A：一种特殊的肌球蛋白。
MYO18A: An unusual myosin.
作者信息
Buschman Matthew D, Field Seth J
机构信息
Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, CA 92093, USA.
Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, CA 92093, USA.
出版信息
Adv Biol Regul. 2018 Jan;67:84-92. doi: 10.1016/j.jbior.2017.09.005. Epub 2017 Sep 18.
MYO18A is a divergent member of the myosin family characterized by the presence of an amino-terminal PDZ domain. MYO18A has been found in a few different complexes involved in intracellular transport processes. MYO18A is found in a complex with LURAP1 and MRCK that functions in retrograde treadmilling of actin. It also has been found in a complex with PAK2, βPIX, and GIT1, functioning to transport that protein complex from focal adhesions to the leading edge. Finally, a high proportion of MYO18A is found in complex with GOLPH3 at the trans Golgi, where it functions to promote vesicle budding for Golgi-to-plasma membrane trafficking. Interestingly, MYO18A has been implicated as a cancer driver, as have other components of the GOLPH3 pathway. It remains uncertain as to whether or not MYO18A has intrinsic motor activity. While many questions remain, MYO18A is a fascinatingly unique myosin that is essential in higher organisms.
MYO18A是肌球蛋白家族的一个不同成员，其特征是存在一个氨基末端PDZ结构域。MYO18A已在一些参与细胞内运输过程的不同复合物中被发现。MYO18A存在于与LURAP1和MRCK形成的复合物中，该复合物在肌动蛋白的逆行踏车运动中发挥作用。它也存在于与PAK2、βPIX和GIT1形成的复合物中，其功能是将该蛋白复合物从粘着斑运输到前沿。最后，在反式高尔基体中发现高比例的MYO18A与GOLPH3形成复合物，在那里它促进从高尔基体到质膜运输的囊泡出芽。有趣的是，MYO18A与GOLPH3途径的其他成分一样，被认为是癌症驱动因子。MYO18A是否具有内在运动活性仍不确定。虽然仍有许多问题，但MYO18A是一种极其独特的肌球蛋白，在高等生物中至关重要。
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