Kothari Vijay, Sharma Sakshi, Padia Divya
Institute of Science, Nirma University, Ahmedabad 382481, India.
Institute of Science, Nirma University, Ahmedabad 382481, India.
Asian Pac J Trop Med. 2017 Aug;10(8):744-752. doi: 10.1016/j.apjtm.2017.07.022. Epub 2017 Aug 19.
Chromobacterium violaceum is a gram-negative bacterium, which has been used widely in microbiology labs involved in quorum sensing (QS) research. Among the QS-regulated traits of this bacterium, violacein production has received the maximum attention. Violacein production in this organism, however is not under sole control of QS machinery, and other QS-regulated traits of this bacterium also need to be investigated in better detail. Though not often involved in human infections, this bacterium is being viewed as an emerging pathogen. This review attempts to highlight the recent research advances on C. violaceum, with respect to violacein biosynthesis, development of various applications of this bacterium and its bioactive metabolite violacein, and its pathogenicity.
紫色杆菌是一种革兰氏阴性细菌，已广泛应用于参与群体感应（QS）研究的微生物实验室。在这种细菌的QS调控特性中，紫色菌素的产生受到了最大关注。然而，这种生物体中紫色菌素的产生并非仅受QS机制的控制，该细菌的其他QS调控特性也需要更详细地研究。尽管这种细菌不常引起人类感染，但它正被视为一种新兴病原体。本综述试图突出紫色杆菌在紫色菌素生物合成、该细菌及其生物活性代谢产物紫色菌素的各种应用开发以及其致病性方面的最新研究进展。
