Spencer G S, Hallett K G, Fadlalla A M, Spencer E M
Animal Physiology Division, AFRC Meat Research Institute, Langford, Bristol, U.K.
Endocrinol Exp. 1987 Dec;21(4):299-306.
The time-related changes in the plasma levels of growth hormone, insulin, somatomedin C and thyroxine following immunization against somatostatin, have been examined in sheep. In both the treated and control lambs there was a significant increase (P less than 0.01) in growth hormone levels with time from the start of the study (at three weeks of age) through until 13 weeks of age. This increase was mirrored by increasing somatomedin C (IGF-1) levels (P less than 0.001). Thyroxine levels did not change during the period of the study. Immunization against somatostatin did not produce any significant difference between treatment groups or between sexes in the levels of growth hormone or thyroxine. However, IGF-1 level were significantly increased (P less than 0.01) by the treatment in both sexes. The changes in the levels of insulin were complicated by a marked difference between the control groups; the control females being significantly different (P less than 0.001) from all the other animals.
在绵羊中，已对注射生长抑素疫苗后血浆中生长激素、胰岛素、生长调节素C和甲状腺素水平随时间的变化进行了研究。从研究开始（三周龄）到13周龄，处理组和对照组羔羊的生长激素水平均随时间显著升高（P<0.01）。生长调节素C（IGF-1）水平的升高与之相呼应（P<0.001）。在研究期间，甲状腺素水平没有变化。注射生长抑素疫苗后，处理组之间或不同性别之间的生长激素或甲状腺素水平没有显著差异。然而，两性的IGF-1水平均因处理而显著升高（P<0.01）。胰岛素水平的变化因对照组之间的显著差异而变得复杂；对照雌性与所有其他动物有显著差异（P<0.001）。
