Cohen A T
Intensive Care Unit, St James's Hospital, Leeds, UK.
Eur J Anaesthesiol Suppl. 1987;1:63-6.
A sedative regimen for use in intensive care based on an i.v. infusion of alfentanil has been evaluated in 32 patients. The mean duration of stay was 7.7 days and the total dose of alfentanil given ranged from 7 to 2308 mg. Most patients required 2-3 mg h-1 of alfentanil supplemented with an hypnotic to provide sleep. The technique was judged successful and was well tolerated by patients. No significant side-effects were observed and the wakefulness of the patients was a prominent feature. Weaning from mechanical ventilation was performed while maintaining the infusion in a number of patients, and in these there was no prolonged respiratory depression.
一种基于静脉输注阿芬太尼的用于重症监护的镇静方案已在32例患者中进行了评估。平均住院时间为7.7天，阿芬太尼的总给药剂量为7至2308毫克。大多数患者需要2 - 3毫克/小时的阿芬太尼，并辅以催眠药以助睡眠。该技术被判定为成功，患者耐受性良好。未观察到明显的副作用，患者清醒是一个突出特点。在一些患者中，在维持输注的同时进行了机械通气撤机，且这些患者未出现呼吸抑制延长的情况。
