[Expression of class II genes in regulatory T-lymphocyte populations in mice and the possible mechanism of genetic restriction of region I of the H-2 complex].

Some contradictions exist in molecular and classical mapping of genes controlling I-J and I-AT (Iat) determinants of the T suppressor and T helper murine lymphocytes. There is strong evidence in favour of the hypothesis that lat molecules function as components of the T receptor for self Ia proteins in a I-restricted manner. These data are discussed from the point of view that beta-genes of the I region of the H-2 complex may control Iat determinants of regulatory T lymphocytes' receptors. A hypothesis is proposed that the I-region-determined restriction is based on interactions between alpha-chains of Ia molecules on A cells and beta-chains of receptors on T lymphocytes.