van Ballegooijen A J, Beulens J W
Department of Health Sciences, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, De Boelelaan 1085, 1081 HV Amsterdam, the Netherlands.
Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, the Netherlands.
Curr Nutr Rep. 2017;6(3):197-205. doi: 10.1007/s13668-017-0208-8. Epub 2017 Jul 10.
Vitamin K is a fat-soluble vitamin required for the activation of several vitamin K-dependent proteins to confer functioning. A growing body of evidence supports that vitamin K has beneficial effects on bone and cardiovascular health. This review summarizes key evidence on vitamin K status as measured by circulating measures and cardiovascular outcomes.
Overall, observational studies indicate that low vitamin K status as measured by high dephosphorylated uncarboxylated matrix gla protein concentrations plays a potential role in cardiovascular disease development, particularly in high-risk and chronic kidney disease populations. Very few vitamin K intervention trials have been conducted with cardiovascular-related outcomes. A couple of intervention trials studied the effect of the combination of vitamin D + K supplementation, which might have synergistic effects compared to vitamin K supplementation alone.
Assessing vitamin K status in prospective studies and well-designed randomized trials would provide important insight whether vitamin K is causally related to vascular calcification and cardiovascular disease.
维生素K是一种脂溶性维生素,是激活多种维生素K依赖蛋白以发挥功能所必需的。越来越多的证据支持维生素K对骨骼和心血管健康有益。本综述总结了通过循环指标测量的维生素K状态及心血管结局的关键证据。
总体而言,观察性研究表明,以高去磷酸化未羧化基质Gla蛋白浓度衡量的低维生素K状态在心血管疾病发展中起潜在作用,尤其是在高危和慢性肾病人群中。很少有针对心血管相关结局进行的维生素K干预试验。有几项干预试验研究了维生素D+K联合补充的效果,与单独补充维生素K相比可能具有协同作用。
在前瞻性研究和设计良好的随机试验中评估维生素K状态,将为维生素K是否与血管钙化和心血管疾病存在因果关系提供重要见解。