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螺旋断层放疗治疗滤泡性弥漫性淋巴瘤的继发性皮肤受累情况

Secondary Cutaneous Involvement in Follicular Diffuse Lymphoma Treated with Helical Tomotherapy.

作者信息

Dar A Rashid, Jordan Kevin, Yartsev Slav

机构信息

Department of Radiation Oncology, London Regional Cancer Program, Western University.

Physics, London Regional Cancer Program, Western University.

出版信息

Cureus. 2017 Jul 14;9(7):e1471. doi: 10.7759/cureus.1471.

Abstract

Non-Hodgkin's lymphoma is a complex heterogeneous group of disease entities that involves nodal and extranodal tissues. Cutaneous involvement can occur either as a primary or secondary in course of disease. Radiation therapy with either total body or localized treatments is often used for local control and symptom relief, depending on the target volume. We describe a 60-year-old male with a remote history of stage IA left neck follicular lymphoma treated with radiation 20 years ago and previous relapses aggressively treated by chemotherapy. Treatment to a large volume of back and posterior shoulders on a helical tomotherapy radiotherapy system is reported. The skin lesions responded completely with no toxicity. Palliative radiotherapy to a fairly large and complex volume of skin with modest dose avoiding underlying critical tissues on tomotherapy is feasible, well tolerated with an excellent durable response, without compromising future chemotherapy and stem cell transplant for systemic relapse.

摘要

非霍奇金淋巴瘤是一组复杂的异质性疾病实体,累及淋巴结和结外组织。皮肤受累可在疾病过程中作为原发性或继发性出现。根据靶区体积,全身或局部放疗常用于局部控制和症状缓解。我们描述了一名60岁男性,20年前因IA期左颈部滤泡性淋巴瘤接受放疗,既往复发时积极接受化疗。报道了在螺旋断层放疗系统上对背部和后肩部的大体积区域进行治疗。皮肤病变完全缓解且无毒性。在断层放疗中,对相当大且复杂的皮肤区域进行适度剂量的姑息性放疗,避免照射下方的关键组织是可行的,耐受性良好,有出色的持久反应,且不影响未来针对全身复发的化疗和干细胞移植。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cb3/5598867/ccbdfb5ca975/cureus-0009-00000001471-i01.jpg

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