Chobanian A
Cardiovascular Institute, Boston University School of Medicine, MA 02118.
J Hypertens Suppl. 1987 Dec;5(4):S43-8. doi: 10.1097/00004872-198712004-00008.
This paper reviews published data concerning the effects of antihypertensive drugs on the development of atherosclerosis in experimental animal models with hyperlipoproteinaemia. Emphasis is placed on the influence of calcium channel antagonists on this process, and the potential mechanisms responsible for the effect. In addition, studies of the action of beta-receptor antagonists on atherogenesis are also summarized. The results indicate that several antihypertensive drugs may inhibit or retard experimentally-induced atherogenesis, even in normotensive animals, although the mechanisms for the effects remain poorly understood.
本文综述了已发表的有关抗高血压药物对高脂蛋白血症实验动物模型动脉粥样硬化发展影响的数据。重点关注钙通道拮抗剂对这一过程的影响以及造成该效应的潜在机制。此外，还总结了β受体拮抗剂对动脉粥样硬化形成作用的研究。结果表明，几种抗高血压药物可能抑制或延缓实验性诱导的动脉粥样硬化形成，即使在血压正常的动物中也是如此，尽管其作用机制仍知之甚少。
