在干燥迷宫中进行延迟位置匹配任务以测量小鼠的空间工作记忆
Delayed-matching-to-place Task in a Dry Maze to Measure Spatial Working Memory in Mice.
作者信息
Feng Xi, Krukowski Karen, Jopson Timothy, Rosi Susanna
机构信息
Brain and Spinal Injury Center, University of California San Francisco, San Francisco, California, USA.
Departments of Physical Therapy and Rehabilitation Science, University of California San Francisco, San Francisco, California, USA.
出版信息
Bio Protoc. 2017 Jul 5;7(13). doi: 10.21769/BioProtoc.2389.
Abstract
The delayed-matching-to-place (DMP) dry maze test is a variant of DMP water maze (Steele and Morris, 1999; Faizi , 2012) which measures spatial working/episodic-like learning and memory that depends on both hippocampal and cortical functions (Wang and Morris, 2010; Euston , 2012). Using this test we can detect normal aging related spatial working memory decline, as well as trauma induced working memory deficits. Furthermore, we recently reported that fractionated whole brain irradiation does not affect working memory in mice (Feng , 2016). Here we describe the experimental setup and procedures of this behavioral test.
摘要
延迟位置匹配（DMP）干迷宫试验是DMP水迷宫的一种变体（斯蒂尔和莫里斯，1999年；法伊齐，2012年），用于测量依赖海马体和皮质功能的空间工作/情景样学习与记忆（王和莫里斯，2010年；尤斯顿，2012年）。通过这个试验，我们可以检测与正常衰老相关的空间工作记忆衰退，以及创伤引起的工作记忆缺陷。此外，我们最近报道，分次全脑照射不会影响小鼠的工作记忆（冯，2016年）。在此，我们描述这种行为试验的实验装置和步骤。
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