Malhi J S, Gard P R, Hanlon G W, Marriott C
Department of Pharmacy, Brighton Polytechnic, Moulsecoomb, Brighton, UK.
J Pharm Pharmacol. 1987 Dec;39(12):1025-8. doi: 10.1111/j.2042-7158.1987.tb03153.x.
This study used guinea-pigs as a mammalian model to investigate the effects of bromhexine hydrochloride and S-carboxymethyl-L-cysteine on the integrity of the cervical mucus plug. It was shown that under normal circumstances the uterus is sterile, but following drug administration microorganisms began to appear in the uterus with no significant effect on the vaginal microbial population. It therefore appears that these two mucolytic agents may reduce cervical mucus viscoelasticity. After the animals had been mated, microorganisms were isolated from the uterus even in the absence of drug treatment.
本研究以豚鼠作为哺乳动物模型，研究盐酸溴己新和S-羧甲基-L-半胱氨酸对宫颈黏液栓完整性的影响。结果表明，在正常情况下子宫是无菌的，但给药后子宫内开始出现微生物，而对阴道微生物群落无显著影响。因此，这两种黏液溶解剂似乎可能降低宫颈黏液的黏弹性。动物交配后，即使在未进行药物治疗的情况下，也能从子宫中分离出微生物。
