Bennett A, Melhuish P B, Stamford I F
Department of Surgery, King's College School of Medicine and Dentistry, Rayne Institute, London, UK.
J Pharm Pharmacol. 1987 Dec;39(12):1039-41. doi: 10.1111/j.2042-7158.1987.tb03158.x.
The question of whether vasodilator nitrates act by releasing prostacyclin is controversial. Since the ability of blood vessels to form prostacyclin changes with age, we have investigated whether this may explain the discrepancies in the literature. It does not, since isosorbide dinitrate or glyceryl trinitrate incubated with rat aorta or vena cava from male Wistar rats had little or no effect on the release of prostacyclin, measured as 6-keto-PGF1 alpha. We confirm that the aorta produces substantially more prostacyclin than the vena cava. The arterial production of prostacyclin was greater in rats weighing 350-400 g than in those weighing 116-152 g, but the production by the veins was similar in both groups.
血管扩张剂硝酸盐是否通过释放前列环素起作用这一问题存在争议。由于血管形成前列环素的能力会随年龄变化，我们研究了这是否可以解释文献中的差异。但事实并非如此，因为用雄性Wistar大鼠的主动脉或腔静脉孵育的硝酸异山梨酯或硝酸甘油对前列环素的释放（以6-酮-PGF1α衡量）几乎没有影响。我们证实主动脉产生的前列环素比腔静脉多得多。体重350 - 400克的大鼠动脉中前列环素的生成量比体重116 - 152克的大鼠多，但两组静脉中的生成量相似。
