COL11A1基因4603C/T多态性与大学生摔跤运动员颈椎间盘退变的相关性
Association of COL11A1 4603C/T polymorphism with cervical disc degeneration in collegiate wrestlers.
作者信息
Koyama Koji, Nakazato Koichi, Maeda Shogo, Kikuchi Naoki, Matsumoto Shingo, Hiranuma Kenji
机构信息
Department of Judotherapy, Tokyo Ariake University of Medical and Health Science, Tokyo, Japan -
Graduate Schools of Health and Sport Science, Nippon Sport Science University, Yokohama, Japan.
出版信息
J Sports Med Phys Fitness. 2018 Nov;58(11):1695-1700. doi: 10.23736/S0022-4707.17.07724-6. Epub 2017 Sep 22.
BACKGROUND
The authors previously identified that COL11A1 gene polymorphism is not a susceptibility factor for lumbar disc degeneration (LDD) in athletes. However, the relationship between COL11A1 gene polymorphism and cervical disc degeneration (CDD) remains unclear. We hypothesized that significant associations between COL11A1 4603C/T gene polymorphism and CDD, but not LDD, in collegiate wrestlers exist. This study aims to examine the relationship between CDD, LDD, and COL11A1 4603C/T gene polymorphism in collegiate wrestlers.
METHODS
The subjects enrolled in this study were 92 (Study-1) and 123 (Study-2) Japanese collegiate male wrestlers. Study-1 and Study-2 were conducted in 2010-2012 and 2012-2015, respectively.
RESULTS
CDD and LDD prevalence among the wrestlers was 51.1% (47/92) and 43.9% (54/123), respectively. We found that COL11A1 4603C/T was significantly associated with CDD, but not with LDD. Using logistic regression analysis with concomitant confounding factors, we further confirmed that COL11A1 4603C/T was a significant risk factor for CDD (co-dominant genetic model [CC vs. CT+TT]: adjusted odds ratio [OR] 2.28; 95% CI: 1.13-4.59; dominant genetic model [CC+CT vs. TT]: adjusted OR 11.71; 95% CI: 1.36-101.06).
CONCLUSIONS
Results suggest that COL11A1 4603C/T gene polymorphism is associated with an increased risk of CDD, but not LDD, in Japanese collegiate wrestlers.
背景
作者之前已确定，COL11A1基因多态性并非运动员腰椎间盘退变（LDD）的易感因素。然而，COL11A1基因多态性与颈椎间盘退变（CDD）之间的关系仍不明确。我们推测，美国大学摔跤运动员中，COL11A1 4603C/T基因多态性与CDD存在显著关联，但与LDD无关。本研究旨在探讨美国大学摔跤运动员中CDD、LDD与COL11A1 4603C/T基因多态性之间的关系。
方法
本研究纳入的受试者为92名（研究1）和123名（研究2）日本大学男摔跤运动员。研究1和研究2分别于2010 - 2012年和2012 - 2015年进行。
结果
摔跤运动员中CDD和LDD的患病率分别为51.1%（47/92）和43.9%（54/123）。我们发现COL11A1 4603C/T与CDD显著相关，但与LDD无关。通过对伴随混杂因素进行逻辑回归分析，我们进一步证实COL11A1 4603C/T是CDD的显著危险因素（共显性遗传模型[CC与CT + TT]：调整后的比值比[OR] 2.28；95%置信区间：1.13 - 4.59；显性遗传模型[CC + CT与TT]：调整后的OR 11.71；95%置信区间：1.36 - 101.06）。
结论
结果表明，在日本大学摔跤运动员中，COL11A1 4603C/T基因多态性与CDD风险增加相关，但与LDD无关。
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