Wei Jing-Chen, Wang Peng-Cheng, Zhou Xian-Li, Tang Kun, Luo Qin, Xu Qin, Chen Xue-Jiao, Liang Cheng-Qin, Chen Xu
a College of Pharmacy , Guilin Medical University , Guilin 541004 , China.
b Guangxi Key Laboratory of Molecular Medicine in Liver Injury and Repair , Guilin Medical University , Guilin 541001 , China.
J Asian Nat Prod Res. 2018 Aug;20(8):757-762. doi: 10.1080/10286020.2017.1357549. Epub 2017 Sep 25.
Five caffeoyl phenylethanoid glycosides, including two new ones linderruelliosides A (1) and B (2), were isolated from the leaves and stems of Lindernia ruellioides. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR and MS spectra. In addition, all these compounds were tested for their anti-HBV activity. Compounds 1, 3, and 4 showed anti-HBV activities, with IC values of 54.87, 30.74, and 69.02 μM for HBsAg and 26.70, 5.17, and 7.08 μM for HBeAg, respectively.
从母草（Lindernia ruellioides）的叶和茎中分离出5种咖啡酰苯乙醇苷，其中包括2种新的母草苷A（1）和母草苷B（2）。基于光谱方法，包括广泛的核磁共振（NMR）和质谱（MS）光谱，阐明了它们的结构。此外，对所有这些化合物进行了抗乙肝病毒（HBV）活性测试。化合物1、3和4表现出抗HBV活性，对乙肝表面抗原（HBsAg）的半数抑制浓度（IC）值分别为54.87、30.74和69.02 μM，对乙肝e抗原（HBeAg）的IC值分别为26.70、5.17和7.08 μM。
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