一种来自药用植物的类黄酮可阻断乙型肝炎病毒e抗原在乙肝病毒感染的肝细胞中的分泌。
A flavonoid from medicinal plants blocks hepatitis B virus-e antigen secretion in HBV-infected hepatocytes.
作者信息
Shin Min Soo, Kang Eun Hwa, Lee Young Ik
机构信息
Liver Cell Signal Transduction Laboratory, Bioscience Research Division, Korea Research Institute of Bioscience and Biotechnology, Taejon 305-606, Republic of Korea.
出版信息
Antiviral Res. 2005 Sep;67(3):163-8. doi: 10.1016/j.antiviral.2005.06.005.
A flavonoid molecule that showed a unique anti-HBV function was isolated from Phyllanthus urinaria. The molecular formula was determined as C14H6O8 based on FAM-MS analysis and the structure was determined by NMR. The identified flavonoid molecule, ellagic acid, showed unique anti-HBV functions. Ellagic acid did not inhibit either HBV polymerase activity, HBV replication or block HBsAg secretion. Rather, ellagic acid blocks effectively HBeAg secretion in HepG2 2.2.15 cells (IC50=0.07 microg/ml). Since HBeAg is involved in immune tolerance during HBV infection, ellagic acid, a newly identified functional anti-HBV compound, may be a new candidate therapeutic against immune tolerance in HBV-infected individuals.
从叶下珠中分离出一种具有独特抗乙肝病毒功能的黄酮类分子。基于FAM-MS分析确定其分子式为C14H6O8，并通过核磁共振确定其结构。鉴定出的黄酮类分子鞣花酸具有独特的抗乙肝病毒功能。鞣花酸既不抑制乙肝病毒聚合酶活性、乙肝病毒复制，也不阻断乙肝表面抗原的分泌。相反，鞣花酸能有效阻断HepG2 2.2.15细胞中乙肝e抗原的分泌（IC50 = 0.07微克/毫升）。由于乙肝e抗原参与乙肝病毒感染期间的免疫耐受，鞣花酸作为一种新鉴定出的具有抗乙肝病毒功能的化合物，可能是治疗乙肝病毒感染个体免疫耐受的新候选药物。
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