溶组织内阿米巴致病和非致病分离株的免疫分化

Immunological differentiation of pathogenic and non-pathogenic isolates of Entamoeba histolytica.

作者信息

Strachan W D, Chiodini P L, Spice W M, Moody A H, Ackers J P

机构信息

Department of Medical Protozoology, London School of Hygiene and Tropical Medicine.

出版信息

Lancet. 1988 Mar 12;1(8585):561-3. doi: 10.1016/s0140-6736(88)91355-4.

DOI:10.1016/s0140-6736(88)91355-4

PMID:2894495

Abstract

Entamoeba histolytica can act as a harmless commensal organism in the lumen of the large intestine, or can cause invasive amoebiasis. Some workers have suggested that there are two distinct subspecies of this organism, and that only one of these is associated with invasive disease. Present isoenzyme tests to identify the subspecies take several days to analyse: we report a technique that uses immunofluorescence with monoclonal antibodies, takes two days to perform, and may, therefore, assist in the clinical management of patients infected with this organism.

摘要

溶组织内阿米巴在大肠肠腔中可作为无害的共生生物，也可引发侵袭性阿米巴病。一些研究人员认为该生物存在两个不同的亚种，且只有其中一个亚种与侵袭性疾病有关。目前用于鉴定亚种的同工酶检测需要数天时间进行分析：我们报告了一种利用单克隆抗体免疫荧光技术的方法，该方法只需两天即可完成，因此可能有助于对感染这种生物的患者进行临床管理。