Tan He-Xin, Xiao Ling, Zhou Zheng, Zhang Lei, Chen Wan-Sheng
Department of Pharmaceutical Botany, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
Zhongguo Zhong Yao Za Zhi. 2017 Jan;42(1):10-19. doi: 10.19540/j.cnki.cjcmm.20161222.019.
Artemisinin-based combination therapy (ACT) is the best available treatment, particularly for Plasmodium falciparum malaria. Artemisinin, whose main source is Artemisia annua, has large demand and shortsupply every year.Artemisininis synthesized,stored, and secreted by the glandular secretory trichomes of A. annua(AaGSTs).In general, the population and morphology of AaGSTs are often positively correlated with artemisinin content.This review article introduces the molecular mechanism of biosynthesis and regulation of artemisininin A. annua. Furthermore, this article will refresh the classification of trichomes in A. annua and provide anoverview of the recent achievements regarding AaGSTs and artemisinin.These will shed light on exploring the method for increasing plant-derived artemisinin.
以青蒿素为基础的联合疗法（ACT）是目前可用的最佳治疗方法，尤其适用于恶性疟原虫疟疾。青蒿素的主要来源是黄花蒿，每年都有大量需求且供应短缺。青蒿素由黄花蒿的腺毛分泌毛状体（AaGSTs）合成、储存和分泌。一般来说，AaGSTs的数量和形态通常与青蒿素含量呈正相关。这篇综述文章介绍了黄花蒿中青蒿素生物合成和调控的分子机制。此外，本文将更新黄花蒿中毛状体的分类，并概述关于AaGSTs和青蒿素的最新研究成果。这些将为探索增加植物源青蒿素的方法提供线索。
