分化型甲状腺癌患者接受放射性碘治疗后眼表疾病、口干症和鼻部症状之间的相关性：一项前瞻性对照研究。
Correlation among ocular surface disease, xerostomia, and nasal symptoms in patients with differentiated thyroid carcinoma subjected to radioiodine therapy: A prospective comparative study.
作者信息
da Fonseca Fabricio Lopes, Yamanaka Patricia Kazue, Mazoti Luciana, Arakawa-Sugueno Lica, Kato Juliana Mika, Matayoshi Suzana
机构信息
Department of Ophthalmology, Medical School, University of São Paulo, São Paulo, Brazil.
Department of Otorhinolaryngology, Medical School, University of São Paulo, São Paulo, Brazil.
出版信息
Head Neck. 2017 Dec;39(12):2381-2396. doi: 10.1002/hed.24895. Epub 2017 Sep 25.
BACKGROUND
Some complications of radioiodine therapy have been reported, but the involvement of the eyes and adnexa is rarely discussed. The purpose of this study was to determine the correlation among ocular surface changes, xerostomia, and changes in the nasal mucosa associated with radioiodine therapy.
METHODS
Patients subjected to radioiodine therapy (group 1) or not subjected (group 2) were prospectively evaluated by examinations of the ocular surface and tear film, saliva production, and nasal endoscopy. Ocular and nasal symptoms and xerostomia were evaluated using questionnaires.
RESULTS
Evaluation of the ocular surface did not indicate significant differences between the groups. Nasal endoscopy revealed higher mucosal pallor in group 1 and worsening of the endoscopic appearance. Worsening of ocular symptoms and nasal symptoms, xerostomia, and a significant decrease in salivary production was also observed in group 1.
CONCLUSION
Subjective worsening of xerostomia, xerophthalmia, nasal symptoms, and changes in the nasal mucosa in group 1 was observed.
背景
放射性碘治疗的一些并发症已有报道，但眼部及附属器受累情况很少被讨论。本研究的目的是确定放射性碘治疗相关的眼表变化、口干症和鼻黏膜变化之间的相关性。
方法
对接受放射性碘治疗的患者（第1组）和未接受治疗的患者（第2组）进行前瞻性评估，检查眼表和泪膜、唾液分泌及鼻内镜检查。使用问卷评估眼部和鼻部症状以及口干症。
结果
眼表评估显示两组之间无显著差异。鼻内镜检查发现第1组黏膜苍白程度更高，内镜表现恶化。第1组还观察到眼部症状和鼻部症状恶化、口干症以及唾液分泌显著减少。
结论
观察到第1组患者主观上出现口干症、干眼症、鼻部症状恶化以及鼻黏膜变化。
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