Department of Head and Neck Surgery and Otorhinolaryngology, Hospital A.C. Camargo, São Paulo, Brazil.
Head Neck. 2011 May;33(5):686-90. doi: 10.1002/hed.21520. Epub 2010 Nov 10.
The purpose of this study was to assess the late side effects of radioiodine therapy (RIT) on salivary gland function. One hundred eighty two patients were evaluated.
Assessment of salivary gland function was performed with salivary gland scintigraphy (SGS), sialometry, and subjective open questions to determine common side effects of RIT on salivary gland function.
RIT had a strong association with decreased elimination counts by SGS. Patient age was the only variable associated with sialometry; age and the use of xerostomic drugs were strongly associated with decreased mean values of salivary flow. Dysphagia was strongly associated with RIT. Using multiple logistic regression analysis, age was determined to be an important factor associated with salivary gland dysfunction, and RIT was associated with impairment of saliva excretion.
These results show that patients subjected to RIT have more difficulty in draining saliva, mainly from the parotid glands, which is associated with clinical dysphagia in this subset of patients.
本研究旨在评估放射性碘治疗 (RIT) 对唾液腺功能的晚期副作用。对 182 名患者进行了评估。
通过唾液腺闪烁扫描 (SGS)、唾液量测定和主观开放性问题评估唾液腺功能，以确定 RIT 对唾液腺功能的常见副作用。
RIT 与 SGS 中排泄计数的减少有很强的相关性。患者年龄是唯一与唾液量测定相关的变量；年龄和使用口干药物与唾液流量的平均值显著降低相关。吞咽困难与 RIT 强烈相关。使用多元逻辑回归分析，年龄被确定为与唾液腺功能障碍相关的重要因素，RIT 与唾液排泄功能受损相关。
这些结果表明，接受 RIT 的患者在排出唾液方面存在更多困难，主要来自腮腺，这与该患者亚组的临床吞咽困难有关。
