Policy Analysis Inc (PAI), Brookline, Massachusetts.
Kessler Institute for Rehabilitation, West Orange, New Jersey.
Neurosurgery. 2018 Sep 1;83(3):445-451. doi: 10.1093/neuros/nyx425.
The lifetime economic burden of thoracic spinal cord injury (SCI) is known to be high, but evidence of variability of costs in relation to the American Spinal Injury Association Impairment Scale (AIS) grade is limited.
To estimate lifetime economic costs of hospitalization by AIS grade in thoracic SCI.
Using SCI Model Systems data from January 2000 to March 2016 from the National Spinal Cord Injury Statistical Center, we estimated mean total annual days of all-cause hospitalization by AIS grade among persons with thoracic SCI, based on assessments 1, 5, and 10 yr post-injury. We combined this information with secondary cost data and projections of life expectancy to estimate lifetime economic costs of hospitalization by AIS grade in persons aged 35 yr at time of thoracic SCI. Future costs were discounted to present value at 3% annually.
One year post-injury, mean total annual days of hospitalization ranged from 2.1 for persons with AIS-D injuries to 5.9 for those who were AIS-A. Similar differences were noted 5 and 10 yr post-SCI. The estimated net present value of expected lifetime costs of hospitalization following thoracic SCI at age 35 yr was $321 534, $249 514, $188 989, and $68 120 (2015 US$) for AIS-A, AIS-B, AIS-C, and AIS-D injuries, respectively.
Persons with less severe thoracic SCI, as reflected in AIS grade, spend fewer days in hospital over their lifetimes, leading to lower costs of inpatient care. Therapies improving AIS grade following thoracic SCI may provide cost savings in addition to addressing substantial unmet need.
已知胸段脊髓损伤(SCI)的终生经济负担很高,但有关美国脊髓损伤协会损伤分级(AIS)与成本相关性的证据有限。
根据胸段 SCI 的 AIS 分级估计住院的终生经济成本。
利用国家脊髓损伤统计中心 SCI 模型系统从 2000 年 1 月至 2016 年 3 月的数据库,我们根据损伤后 1、5 和 10 年的评估,估计了胸段 SCI 患者中 AIS 分级的所有原因住院的平均年住院天数。我们将此信息与次要成本数据和预期寿命预测相结合,以估计 35 岁时患有胸段 SCI 的患者的 AIS 分级的终生住院经济成本。未来成本按每年 3%贴现至现值。
损伤后 1 年,住院平均年总天数从 AIS-D 损伤患者的 2.1 天到 AIS-A 患者的 5.9 天不等。在 SCI 后 5 年和 10 年也观察到类似的差异。35 岁时患有胸段 SCI 的患者,预计终生住院费用的净现值为 AIS-A、AIS-B、AIS-C 和 AIS-D 损伤的 321534 美元、249514 美元、188989 美元和 68120 美元(2015 年美元)。
AIS 分级反映的较轻微胸段 SCI 的患者在一生中住院天数较少,导致住院费用较低。改善胸段 SCI 后 AIS 分级的治疗方法除了满足大量未满足的需求外,还可能节省成本。