Thaung Zaw Jay Jay, Howe Peter Ranald Charles, Wong Rachel Heloise Xiwen
Clinical Nutrition Research Centre, School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia.
Division of Research and Innovation, University of Southern Queensland, Raceview, Queensland, Australia.
Ann N Y Acad Sci. 2017 Sep;1403(1):150-163. doi: 10.1111/nyas.13459.
Recent evidence indicates that resveratrol, a phytoestrogen, can improve cognitive function in postmenopausal women by enhancing cerebral vasodilator responsiveness. We examine the effects of phytoestrogen supplementation on cognition and compare resveratrol with other phytoestrogens. Databases were searched for reports of randomized controlled trials (RCTs) containing terms describing phytoestrogens together with terms relating to cognition. Effect sizes were determined for changes in cognition. We identified 23 RCTs, 15 with isoflavone and eight with resveratrol or grape formulations. Six soy isoflavone studies showed positive cognitive effects of medium size. Greater benefits were seen in women who were <10 years postmenopausal and supplemented for <6 months. Small-to-medium effect-size cognitive benefits of resveratrol were seen in four studies of older adults of mixed gender and in postmenopausal women who took 150-200 mg resveratrol daily for at least 14 weeks. No benefits were seen in three studies using red clover or grape formulations. Supplementation with either soy isoflavone or resveratrol improved executive function and memory domains of cognitively normal older adults in half of the included studies, mostly with medium effect sizes. The cognitive benefit of resveratrol was related to improved cerebral perfusion.
近期证据表明，白藜芦醇这种植物雌激素可通过增强脑血管舒张反应性来改善绝经后女性的认知功能。我们研究了补充植物雌激素对认知的影响，并将白藜芦醇与其他植物雌激素进行比较。检索数据库以查找随机对照试验（RCT）报告，这些报告包含描述植物雌激素的术语以及与认知相关的术语。确定认知变化的效应量。我们识别出23项RCT，其中15项是关于异黄酮的，8项是关于白藜芦醇或葡萄制剂的。六项大豆异黄酮研究显示出中等程度的积极认知效应。绝经后不到10年且补充时间不到6个月的女性受益更大。在四项针对不同性别的老年人以及绝经后女性的研究中，这些女性每天服用150 - 200毫克白藜芦醇至少14周，观察到白藜芦醇有小到中等效应量的认知益处。在三项使用红三叶草或葡萄制剂的研究中未观察到益处。在纳入研究的一半中，补充大豆异黄酮或白藜芦醇可改善认知正常的老年人的执行功能和记忆领域，大多为中等效应量。白藜芦醇的认知益处与脑灌注改善有关。
