Zhao Qingying, Li Min, Luo Jun
Technol Health Care. 2017 Dec 4;25(6):1119-1130. doi: 10.3233/THC-171016.
In nanomachine applications towards targeted drug delivery, drug molecules released by nanomachines propagate and chemically react with tumor cells in aqueous environment. If the nanomachines release drug molecules faster than the tumor cells react, it will result in loss and waste of drug molecules. It is a potential issue associated with the relationship among reaction rate, release rate and efficiency.
This paper aims to investigate the relationship among reaction rate, release rate and efficiency based on two drug reception models. We expect to pave a way for designing a control method of drug release.
We adopted two analytical methods that one is drug reception process based on collision with tumors and another is based on Michaelis Menten enzymatic kinetics. To evaluate the analytical formulations, we used the well-known simulation framework N3Sim to establish simulations.
The analytical results of the relationship among reaction rate, release rate and efficiency is obtained, which match well with the numerical simulation results in a 3-D environment.
Based upon two drug reception models, the results of this paper would be beneficial for designing a control method of nanomahine-based drug release.
在纳米机器用于靶向给药的应用中，纳米机器释放的药物分子在水性环境中扩散并与肿瘤细胞发生化学反应。如果纳米机器释放药物分子的速度比肿瘤细胞反应的速度快，就会导致药物分子的损失和浪费。这是一个与反应速率、释放速率和效率之间的关系相关的潜在问题。
本文旨在基于两种药物接收模型研究反应速率、释放速率和效率之间的关系。我们期望为设计药物释放的控制方法铺平道路。
我们采用了两种分析方法，一种是基于与肿瘤碰撞的药物接收过程，另一种是基于米氏酶动力学。为了评估分析公式，我们使用著名的模拟框架N3Sim来建立模拟。
获得了反应速率、释放速率和效率之间关系的分析结果，这些结果与三维环境中的数值模拟结果非常吻合。
基于两种药物接收模型，本文的结果将有助于设计基于纳米机器的药物释放控制方法。
