与利妥昔单抗导致的持续性B细胞耗竭相关的埃可病毒9型引起的急性肝衰竭
Acute Liver Failure Due to Echovirus 9 Associated With Persistent B-Cell Depletion From Rituximab.
作者信息
Bajema Kristina L, Simonson Paul D, Greninger Alex L, Çoruh Basak, Pottinger Paul S, Bhattacharya Renuka, Liou Iris W, Jalikis Florencia G, Fligner Corinne L, Rakita Robert M
机构信息
Division of Allergy and Infectious Diseases, Department of Medicine.
Department of Pathology.
出版信息
Open Forum Infect Dis. 2017 Aug 14;4(3):ofx174. doi: 10.1093/ofid/ofx174. eCollection 2017 Summer.
We describe a case of fatal acute liver failure due to echovirus 9 in the setting of persistent B-cell depletion and hypogammaglobulinemia 3 years after rituximab therapy. Metagenomic next-generation sequencing further specified the etiologic agent. Early recognition may provide an opportunity for interventions including intravenous immunoglobulin and liver transplantation.
我们描述了1例在接受利妥昔单抗治疗3年后出现持续性B细胞耗竭和低丙种球蛋白血症的情况下，由埃可病毒9型导致的致命性急性肝衰竭病例。宏基因组下一代测序进一步明确了病原体。早期识别可为包括静脉注射免疫球蛋白和肝移植在内的干预措施提供机会。
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