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免疫功能正常的成年患者感染肠道病毒后发生严重横纹肌溶解症和急性暴发性肝衰竭并需要肝移植:1例病例报告

Enterovirus-Induced Severe Rhabdomyolysis and Acute Fulminant Liver Failure in an Immunocompetent Adult Requiring Liver Transplantation: A Case Report.

作者信息

Angappan Santhalakshmi, Tabbara Abdul Kader, Pawloski Jacob, Chhina Anoop K, Galusca Dragos

机构信息

Anesthesiology/Critical Care, Perioperative Medicine and Pain Management, Henry Ford Health System, Detroit, USA.

Anesthesiology/Critical Care, Henry Ford Health System, Detroit, USA.

出版信息

Cureus. 2022 Apr 21;14(4):e24336. doi: 10.7759/cureus.24336. eCollection 2022 Apr.

Abstract

The authors report a case of a young healthy adult with severe rhabdomyolysis and acute fulminant liver failure with multiple organ dysfunction syndromes (MODS), possibly from an enterovirus infection. To the best of our knowledge, this is the first-ever reported case of enterovirus-induced rhabdomyolysis and acute liver failure (ALF) in an immunocompetent adult. It is vital that the treating physician be aware of the association between viral infections, viral myositis, and severe rhabdomyolysis with acute liver failure, which can facilitate the optimal management of such patients. Prompt recognition may provide an opportunity for early interventions, including intravenous immunoglobulin and liver transplantation, if warranted.

摘要

作者报告了一例年轻健康成年人的病例,该患者患有严重横纹肌溶解症、急性暴发性肝衰竭并伴有多器官功能障碍综合征(MODS),可能由肠道病毒感染引起。据我们所知,这是首例有免疫能力的成年人中由肠道病毒引起横纹肌溶解症和急性肝衰竭(ALF)的报告病例。治疗医生必须意识到病毒感染、病毒性肌炎以及严重横纹肌溶解症与急性肝衰竭之间的关联,这有助于对此类患者进行最佳管理。如果有必要,及时识别可能为早期干预提供机会,包括静脉注射免疫球蛋白和肝移植。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/047c/9123819/f8b52fa8c150/cureus-0014-00000024336-i01.jpg

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