Sasaki Yutaka, Hirooka Yoshiki, Kawashima Hiroki, Ishikawa Takuya, Takeshita Kyosuke, Goto Hidemi
1 Department of Medical Technique, Nagoya University Hospital, Nagoya, Japan.
2 Department of Endoscopy, Nagoya University Hospital, Nagoya, Japan.
Acta Radiol. 2018 Jul;59(7):884-890. doi: 10.1177/0284185117734417. Epub 2017 Sep 26.
Background Chronic kidney disease (CKD) patients have advanced glomerulosclerosis and renal interstitial fibrosis. Shear wave elastography (SWE) is useful to diagnose liver fibrosis. However, there are few data available regarding evaluation of kidney function on the use of SWE. Purpose To assess the utility of SWE by evaluating the correlation between renal function and renal elasticity using SWE. Material and Methods A total of 187 participants who had available serum creatinine levels and also underwent SWE of the kidney using a transabdominal ultrasonography were recruited at Nagoya University Hospital. We measured the depth of the shear wave (SW) in the right and left kidneys and calculated the measurement success rates. The glomerular filtration rate (GFR) classification and shear wave value (SWV) were compared. Results The success rates of the right and left kidneys were 93.6% and 71.6%, respectively. Based on these results, the correlation between GFR classification and SWV were analyzed in only the right kidneys because the success rates and the number of enrolled patients were low for the left kidney. There were significant differences found between G1 and G3a, G2 and G3a, G3a and G3b, G3a and G4, and G3a and G5. SWV significantly negatively and positively correlated with the G2-G3a and G3a-G3b classifications. Conclusion There is no correlation between renal function and SW. However, we can diagnose the progression to the CKD stages G3a and G3b by observing the changes over time using the SWV.
背景 慢性肾脏病（CKD）患者存在严重的肾小球硬化和肾间质纤维化。剪切波弹性成像（SWE）对肝纤维化诊断有用。然而，关于使用SWE评估肾功能的数据较少。目的 通过评估肾功能与使用SWE的肾弹性之间的相关性来评估SWE的效用。材料与方法 在名古屋大学医院招募了187名有可用血清肌酐水平且接受了经腹部超声肾脏SWE检查的参与者。我们测量了左右肾中剪切波（SW）的深度并计算测量成功率。比较肾小球滤过率（GFR）分级与剪切波值（SWV）。结果 右肾和左肾的成功率分别为93.6%和71.6%。基于这些结果，仅在右肾中分析GFR分级与SWV之间的相关性，因为左肾的成功率和纳入患者数量较低。在G1与G3a、G2与G3a、G3a与G3b、G3a与G4以及G3a与G5之间发现有显著差异。SWV与G2 - G3a和G3a - G3b分级显著负相关和正相关。结论 肾功能与SW之间无相关性。然而，我们可以通过观察SWV随时间的变化来诊断CKD进展至G3a和G3b期。
