Siristatidis Charalampos, Dafopoulos Konstantinos, El-Khayat Waleed, Salamalekis George, Anifandis George, Vrantza Tereza, Elsadek Mostafa, Papantoniou Nikolaos
a Assisted Reproduction Unit, Third Department of Obstetrics and Gynecology , "Attikon Hospital", Medical School, National and Kapodistrian University of Athens , Athens , Greece.
b Assisted Reproduction Unit, Department of Obstetrics and Gynecology , University of Thessaly, School of Health Sciences, Faculty of Medicine , Larissa , Greece.
Gynecol Endocrinol. 2018 Feb;34(2):136-139. doi: 10.1080/09513590.2017.1380182. Epub 2017 Sep 26.
Conflicting results exist for low molecular weight heparin (LMWH) and prednisolone when tested as separate adjuncts for the improvement of the clinical outcomes in patients with repeated implantation failures (RIF) undergoing IVF/ICSI treatment. Through a cohort study, we evaluated the combined effect of both drugs on pregnancy parameters in 115 women with RIF. Clinical pregnancy rate was the primary end point while the sample size was calculated through the results of a pilot study. Clinical and IVF cycle characteristics were also compared between the groups. Baseline and cycle characteristics were comparable between groups. Biochemical and clinical pregnancy rates were similar in both groups [23/57 (40.4%) vs. 14/58 (24.1%), and 17/57 (29.8%) vs. 11/58 (19%), p = .063, and .175, respectively]. Similarly, miscarriage rates were comparable between the groups (35.7% vs. 34.8%), as well as live birth rates [15/57 (26.3%) vs. 9/58 (15.5%), p = .154]. In conclusion, the administration of LMWH with prednizolone in subfertile women with RIF seems not to improve clinical pregnancy rates, but a full-scaled RCT would definitely be more accurate.
在作为辅助手段单独测试以改善接受体外受精/卵胞浆内单精子注射（IVF/ICSI）治疗的反复种植失败（RIF）患者的临床结局时，低分子量肝素（LMWH）和泼尼松龙的结果相互矛盾。通过一项队列研究，我们评估了这两种药物对115例RIF女性妊娠参数的联合影响。临床妊娠率是主要终点，样本量通过一项初步研究的结果计算得出。还比较了两组之间的临床和IVF周期特征。两组之间的基线和周期特征具有可比性。两组的生化妊娠率和临床妊娠率相似[分别为23/57（40.4%）对14/58（24.1%），以及17/57（29.8%）对11/58（19%），p = 0.063和0.175]。同样，两组之间的流产率具有可比性（35.7%对34.8%），活产率也是如此[15/57（26.3%）对9/58（15.5%），p = 0.154]。总之，在患有RIF的不育女性中联合使用LMWH和泼尼松龙似乎并不能提高临床妊娠率，但全面的随机对照试验（RCT）肯定会更准确。
