通过 N-杂环卡宾催化的[3+4]环加成反应立体选择性合成功能化的四氢-1H-1,2-二氮杂环。
Stereoselective Synthesis of Functionalized Tetrahydro-1H-1,2-diazepines by N-Heterocyclic Carbene-Catalyzed [3 + 4] Annulation.
机构信息
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University , Lanzhou 730000, P. R. China.
出版信息
Org Lett. 2017 Oct 6;19(19):5380-5383. doi: 10.1021/acs.orglett.7b02657. Epub 2017 Sep 26.
PMID:28949541
Abstract
An efficient N-heterocyclic carbene (NHC)-catalyzed asymmetric [3 + 4] annulation reaction of N-Ts hydrazones with 2-bromoenals has been developed. A series of functionalized tetrahydro-1H-1,2-diazepines with two consecutive stereocenters was obtained using NHCs as the catalyst in good yields with excellent diastereo- and enantioselectivities.
摘要
已开发出一种高效的 N-杂环卡宾 (NHC) 催化的 N-Ts 腙与 2-溴代烯醛的不对称 [3 + 4] 环加成反应。使用 NHC 作为催化剂，以良好的产率和优异的非对映选择性和对映选择性，获得了一系列具有两个连续立体中心的功能化四氢-1H-1,2-二氮杂环。
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