Jackson B, McGrath B P, Johnston C I
Monash University Department of Medicine, Prince Henry's Hospital, Melbourne.
Drugs. 1987;34 Suppl 3:87-92. doi: 10.2165/00003495-198700343-00020.
A study was carried out of 22 patients with essential hypertension who were treated with metoprolol (100 mg/day) and placebo for 4 weeks. Felodipine (n = 11) or prazosin (n = 11) were then added in increasing doses (felodipine 5, 10, 20 mg bid; prazosin 1, 2, 4 mg bid) for 2 weeks until a diastolic blood pressure of less than or equal to 90 mm Hg was achieved. Acute haemodynamic and hormonal responses to 80 degrees tilting (measurements after 4 minutes' tilt) were obtained immediately prior to randomisation to felodipine or prazosin, and after 6 to 8 weeks of treatment. At randomisation, 80 degrees tilt produced no change in blood pressure and only a small increase in pulse rate. There was no significant change in the plasma renin-angiotensin system, vasopressin or adrenaline concentrations. Plasma noradrenaline concentration rose in response to 80 degrees tilt. Following substitution of felodipine (n = 11) or prazosin (n = 11) for placebo, and continuation of metoprolol, blood pressure fell. 80 degrees tilt caused no change in the plasma renin-angiotensin system, vasopressin or adrenaline concentration. Plasma noradrenaline concentration rose in response to tilt, as before. Felodipine is an effective antihypertensive agent when used with metoprolol.(ABSTRACT TRUNCATED AT 250 WORDS)
对22例原发性高血压患者进行了一项研究，这些患者接受美托洛尔（100毫克/天）和安慰剂治疗4周。然后分别给予非洛地平（n = 11）或哌唑嗪（n = 11），剂量逐渐增加（非洛地平每日两次，每次5、10、20毫克；哌唑嗪每日两次，每次1、2、4毫克），持续2周，直至舒张压降至小于或等于90毫米汞柱。在随机分组接受非洛地平或哌唑嗪治疗前以及治疗6至8周后，立即获取急性血流动力学和激素对80度倾斜（倾斜4分钟后测量）的反应。随机分组时，80度倾斜未引起血压变化，仅使心率略有增加。血浆肾素 - 血管紧张素系统、血管加压素或肾上腺素浓度无显著变化。血浆去甲肾上腺素浓度因80度倾斜而升高。用非洛地平（n = 11）或哌唑嗪（n = 11）替代安慰剂并继续使用美托洛尔后，血压下降。80度倾斜未引起血浆肾素 - 血管紧张素系统、血管加压素或肾上腺素浓度变化。血浆去甲肾上腺素浓度如前一样因倾斜而升高。非洛地平与美托洛尔合用时是一种有效的抗高血压药物。（摘要截短至250字）
