Nichols A J, Motley E D, Ruffolo R R
Department of Pharmacology, Smith Kline & French Laboratories, King of Prussia, PA 19406.
Eur J Pharmacol. 1988 Jan 19;145(3):345-9. doi: 10.1016/0014-2999(88)90440-2.
The role of the pertussis toxin-sensitive guanine nucleotide binding regulatory protein in pre- and postjunctional alpha 2-adrenoceptor-mediated responses has been investigated in the pithed rat. Pertussis toxin (50 micrograms/kg i.v., administered 3 days prior to experimentation) markedly inhibited the alpha 2-adrenoceptor-mediated vasopressor response to B-HT 933, but had no effect on the alpha 2-adrenoceptor-mediated cardiac neuroinhibitory effect of B-HT 933. Thus, postjunctional alpha 2-adrenoceptor activation in vascular smooth muscle, but not prejunctional alpha 2-adrenoceptor activation on sympathetic neurons, utilizes a pertussis toxin-sensitive guanine nucleotide binding regulatory protein.
已在脊髓横断大鼠中研究了百日咳毒素敏感的鸟嘌呤核苷酸结合调节蛋白在节前和节后α2 -肾上腺素能受体介导反应中的作用。百日咳毒素（静脉注射50微克/千克，在实验前3天给药）显著抑制了α2 -肾上腺素能受体介导的对B - HT 933的升压反应，但对B - HT 933的α2 -肾上腺素能受体介导的心脏神经抑制作用没有影响。因此，血管平滑肌中的节后α2 -肾上腺素能受体激活，而非交感神经元上的节前α2 -肾上腺素能受体激活，利用了一种百日咳毒素敏感的鸟嘌呤核苷酸结合调节蛋白。
