School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, China.
School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, China.
Int J Biol Macromol. 2018 Feb;107(Pt A):1184-1192. doi: 10.1016/j.ijbiomac.2017.09.096. Epub 2017 Sep 23.
Nanotechnology has been studied to improve drug delivery and cancer treatment. The aim of this study is to introduce amino groups into graphene oxide (GO) to form aminated fumed graphene (GO-ADH) and combine GO-ADH with carboxymethyl cellulose (CMC) to produce GO-CMC complex as a drug carrier matrix. The anti-cancer drug small molecule doxorubicin hydrochloride (DOX) was bond to GO-CMC by π-π bond interaction and hydrogen bonding to form GO-CMC/DOX drug loading system. Via the FT-IR, transmission electron microscopy (TEM) and Zeta potential analyzer analysis showed that GO-CMC complex was successfully synthesized. Studies have shown that when pH=5.0, the cumulative release rate of drugs can reach 65.2%, which means it has pH-sensitive ability. The cells were treated with MTT method and human cervical cancer cells (Hela cells) and mouse fibroblasts (NIH-3T3 cells). The results showed that GO-CMC had no obvious cytotoxicity and good biocompatibility.
纳米技术已经被研究用于改善药物输送和癌症治疗。本研究的目的是将氨基引入氧化石墨烯（GO）中，形成氨基化的烟石墨烯（GO-ADH），并将 GO-ADH 与羧甲基纤维素（CMC）结合，制成 GO-CMC 复合物作为药物载体基质。通过π-π键相互作用和氢键将抗癌小分子盐酸多柔比星（DOX）键合到 GO-CMC 上，形成 GO-CMC/DOX 药物负载系统。通过傅里叶变换红外光谱（FT-IR）、透射电子显微镜（TEM）和 Zeta 电位分析仪分析表明，成功合成了 GO-CMC 复合物。研究表明，当 pH=5.0 时，药物的累积释放率可达 65.2%，这意味着它具有 pH 敏感性。通过 MTT 法处理细胞，用人宫颈癌细胞（Hela 细胞）和小鼠成纤维细胞（NIH-3T3 细胞）进行实验。结果表明，GO-CMC 无明显细胞毒性，具有良好的生物相容性。
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