The Milner Centre for Evolution Biology and Biochemistry, University of Bath, Bath, UK.
Mol Syst Biol. 2017 Sep 26;13(9):943. doi: 10.15252/msb.20177961.
Why are neighbouring genes co‐expressed at the RNA level? While it is tempting to think that this is to enable coordination of functionally related proteins, analysis of human proteomics data by Rappsilber and colleagues (Kustatscher , 2017) suggests this is the exception not the rule. Rather it might either be just something that happens or, in some instances, an epiphenomenon of coordination of expression to enable reduced gene expression noise.
为什么相邻的基因在 RNA 水平上共表达？虽然人们很容易认为这是为了协调功能相关的蛋白质，但 Rappsilber 及其同事对人类蛋白质组学数据的分析（Kustatscher，2017）表明，这种情况并非普遍规律，而是例外。相反，它可能只是偶然发生的事情，或者在某些情况下，是为了协调表达以减少基因表达噪声的表型现象。
