Is intraoperative real-time dosimetry in prostate seed brachytherapy predictive of biochemical outcome?

PURPOSE

To analyze intraoperative (IO) dosimetry using transrectal ultrasound (TRUS), performed before and after prostate low-dose-rate brachytherapy (LDR-BT), and compare it to dosimetry performed 30 days following the LDR-BT implant (Day 30).

MATERIAL AND METHODS

A total of 236 patients underwent prostate LDR-BT using I that was performed with a three-dimensional TRUS-guided interactive inverse preplanning system (preimplant dosimetry). After the implant procedure, the TRUS was repeated in the operating room, and the dosimetry was recalculated (postimplant dosimetry) and compared to dosimetry on Day 30 computed tomography (CT) scans. Area under curve (AUC) statistics was used for models predictive of dosimetric parameters at Day 30.

RESULTS

The median follow-up for patients without BF was 96 months, the 5-year and 8-year biochemical recurrence (BR)-free rate was 96% and 90%, respectively. The postimplant median D was 3.8 Gy lower (interquartile range [IQR], 12.4-0.9), and the V only 1% less (IQR, 2.9-0.2%) than the preimplant dosimetry. When comparing the postimplant and the Day 30 dosimetries, the postimplant median D was 9.6 Gy higher (IQR [-] 9.5-30.3 Gy), and the V was 3.2% greater (0.2-8.9%) than Day 30 postimplant dosimetry. The variables that best predicted the D of Day 30 was the postimplant D (AUC = 0.62, = 0.038). None of the analyzed values for IO or Day 30 dosimetry showed any predictive value for BR.

CONCLUSIONS

Although improving the IO preimplant and postimplant dosimetry improved dosimetry on Day 30, the BR-free rate was not dependent on any dosimetric parameter. Unpredictable factors such as intraprostatic seed migration and IO factors, prevented the accurate prediction of Day 30 dosimetry.