尿 CD80 在原发性肾病综合征复发中的预测性。
Predictability of Urinary CD80 in the Relapse of Primary Nephrotic Syndrome.
机构信息
Department of Pediatric Nephrology, Children's Medical Center, The Second Xiangya Hospital, Central South University, No. 139 Middle Renmin Road, Changsha, Hunan 410011, China.
出版信息
Biomed Res Int. 2017;2017:9429314. doi: 10.1155/2017/9429314. Epub 2017 Aug 29.
PURPOSE
The current study is aimed at investigating whether urinary CD80 is reliable to predict the recurrence of pediatric PNS.
MATERIALS AND METHODS
A total of 128 children, 105 males and 23 females, were enrolled in this study. Urinary samples were collected from SSNS and SRNS patients and 25 healthy children as controls. Urinary CD80 was measured by ELISA and adjusted for urinary creatinine excretion.
RESULTS
Urinary CD80 in relapse stage of SSNS was significantly higher, and the urinary CD80 of paired relapse and remission stages of each SSNS patient were also significantly different. No significant difference was found between the urinary CD80 in SRNS relapse group, SRNS remission group, and the control group. Similarly, there was no significant difference between frequent SSNS and not frequent SSNS in remission group, as well as the relapse group. There is no correlation between urinary CD80 and 24-hour urinary protein.
CONCLUSION
The increase of urinary CD80 was closely associated with the relapse of SSNS but was not related to the frequency of relapse. The urinary CD80 changes of concentration were reliable to predict the recurrence of SSNS. However, it cannot be used to predicate the frequent recurrence of PNS.
目的
本研究旨在探讨尿 CD80 是否可用于预测儿童 PNS 的复发。
材料与方法
共纳入 128 例患儿，男 105 例，女 23 例，其中 SSNS 患儿 75 例，SRNS 患儿 37 例，健康对照儿童 25 例。收集 SSNS 和 SRNS 患儿及健康对照儿童的尿样，采用 ELISA 法检测尿 CD80，并根据尿肌酐排泄进行校正。
结果
SSNS 缓解-复发期患儿尿 CD80 明显升高，且每位 SSNS 患儿缓解-复发期配对尿 CD80 差异均有统计学意义。SRNS 复发组、缓解组患儿尿 CD80 与对照组比较差异无统计学意义。同样，缓解期频繁复发与非频繁复发 SSNS 患儿间，以及复发组与缓解组间，尿 CD80 差异均无统计学意义。尿 CD80 与 24 小时尿蛋白定量无相关性。
结论
尿 CD80 浓度升高与 SSNS 复发密切相关，但与复发频率无关。尿 CD80 浓度变化可用于预测 SSNS 复发，但不能预测 PNS 的频繁复发。
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