Rezk Hassan Ghada Fawzy, Marey Karima
Lecturer of Dermatology and Venereology, Faculty of medicine, Tanta University, 31111, Tanta, Egypt. Email:
Asian Pac J Cancer Prev. 2017 Sep 27;18(9):2493-2499. doi: 10.22034/APJCP.2017.18.9.2493.
Background: Mycosis fungoides (MF) is the commonest variant of primary cutaneous T cell lymphoma with several clinicopathologic variants. Defective apoptotic mechanism may be important in the pathogenesis and progression of MF. c-FLIP protein is an important anti-apoptotic marker and chemotherapeutic resistant factor. This study aimed to evaluate the c-FLIP expression in MF and its role in the pathogenesis of MF. Methods: Twenty patients of MF and ten normal persons were included in this study. Skin biopsies were obtained from both patients and controls. They were studied and examined immunohistochemically for the expression of CD4 and c-FLIP. Results: c-FLIP expression was significantly increased in patients when compared to controls in both epidermis and dermis. There were positive correlations between c-FLIP expression and CD4+ expression in both epidermal and dermal lesions of patients group. There were statistically significant positive correlations between c-FLIP expression (in both dermal and epidermal lesions) and the age of patients. c-FLIP expression increased with the tumor progression but with no statistical significance. Conclusion: Defective regulation of apoptosis has been considered as a main cause for accumulation of clonal T cells, and it was related to an increased expression of c-FLIP which may have a role in the pathogenesis of MF. Also, c-FLIP may have prognostic information in MF as its level increased with both age of the patients and tumor progression.
蕈样肉芽肿（MF）是原发性皮肤T细胞淋巴瘤最常见的亚型，有多种临床病理变异型。凋亡机制缺陷在MF的发病机制和进展中可能起重要作用。c-FLIP蛋白是一种重要的抗凋亡标志物和化疗耐药因子。本研究旨在评估c-FLIP在MF中的表达及其在MF发病机制中的作用。方法：本研究纳入20例MF患者和10名正常人。从患者和对照者身上获取皮肤活检标本。对其进行研究并通过免疫组织化学检测CD4和c-FLIP的表达。结果：与对照组相比，患者表皮和真皮中的c-FLIP表达均显著增加。患者组表皮和真皮病变中c-FLIP表达与CD4+表达之间呈正相关。c-FLIP表达（在真皮和表皮病变中）与患者年龄之间存在统计学显著的正相关。c-FLIP表达随肿瘤进展而增加，但无统计学意义。结论：凋亡调节缺陷被认为是克隆性T细胞积累的主要原因，且与c-FLIP表达增加有关，c-FLIP可能在MF的发病机制中起作用。此外，c-FLIP可能在MF中具有预后信息，因为其水平随患者年龄和肿瘤进展而增加。
