Chalieopanyarwong Virote, Attawettayanon Worapat, Kanchanawanichkul Watid, Pripatnanont Choosak
Division of Urology, Department of Surgery, Faculty of Medicine, Songklanagarind Hospital, Prince of Songkla University, Songkhla, Thailand. Email:
Asian Pac J Cancer Prev. 2017 Sep 27;18(9):2555-2559. doi: 10.22034/APJCP.2017.18.9.2555.
Objective: To evaluate outcomes, biochemical recurrence-free survival (BCRFS) and to identify parameters influencing BCRFS of radical prostatectomy (RP) and bilateral pelvic lymph node dissection in a single-institution. Methods: A retrospective review of prostate cancer (PC) patients received RP was identified from the medical records. Data was collected from 2007 to 2016. 178 patients received RP were enrolled in a study. These patients were evaluated on efficacy of RP by using prostate-specific antigen (PSA) to analyze BCRFS and compared with Gleason score, pathologic staging, margin status and lymph node status with BCRFS. Results: The median follow up was 32.5 months (n = 178). Sixty-nine patients had extracapsular extension on pathologic results whereas 93 patients were classified as a high risk group. The median time for biochemical recurrence (BCR) was 22.3 months. The 3-year BCRFS in patients with a Gleason score 6, 3+4, 4+3, 8 and 9-10 were 85.8%, 84.6%, 78.7%, 53.3% and 35.8% . Multivariate analysis showed that extracapsular extension was independently associated with BCRFS. Conclusions: New group grading system indicates impact on BCRFS on univariate analysis but show negative impact on a multivariate Cox regression, only pathologic staging was independently associated with the cancer control outcome.
在单一机构中评估根治性前列腺切除术（RP）及双侧盆腔淋巴结清扫术的疗效、无生化复发生存率（BCRFS），并确定影响BCRFS的参数。方法：从病历中回顾性分析接受RP的前列腺癌（PC）患者。收集2007年至2016年的数据。178例接受RP的患者纳入研究。通过前列腺特异性抗原（PSA）分析BCRFS来评估这些患者RP的疗效，并将其与Gleason评分、病理分期、切缘状态及淋巴结状态与BCRFS进行比较。结果：中位随访时间为32.5个月（n = 178）。69例患者病理结果显示有包膜外侵犯，93例患者被归类为高危组。生化复发（BCR）的中位时间为22.3个月。Gleason评分为6、3 + 4、4 + 3、8和9 - 10的患者3年BCRFS分别为85.8%、84.6%、78.7%、53.3%和35.8%。多因素分析显示包膜外侵犯与BCRFS独立相关。结论：新的分组分级系统在单因素分析中显示对BCRFS有影响，但在多因素Cox回归中显示为负面影响，只有病理分期与癌症控制结局独立相关。
