a Department of cardiology , Palandoken State Hospital , Erzurum , Turkey.
b Department of biochemistry , Palandoken State Hospital , Erzurum , Turkey.
Clin Exp Hypertens. 2018;40(4):332-336. doi: 10.1080/10641963.2017.1377216. Epub 2017 Sep 27.
High-sensitivity cardiac troponin T (hs-cTNT) is an important non-invasive laboratory-based marker of subclinical myocardial injury. Prehypertension, which may be a precursor of hypertension, is a major public health issue. Our aim was to evaluate the importance of serum hs-cTnT as a marker predicting prehypertension.
A total of 100 subjects (45 women and 55 men) consisting of 50 consecutive prehypertensive patients with blood pressures between 120/80 and 139/89 mmHg and 50 normotensive patients with blood pressures < 120/80 mmHg were enrolled prospectively. The hs-cTNT level was calculated and compared between the two groups. Echocardiographic examinations were performed in all patients.
The hs-cTnT level was significantly higher in the prehypertensive group (p < 0.001) and was positively correlated with prehypertension (r = 0.625, p < 0.001). Hs-cTnT was an independent predictor of prehypertension (odds ratio = 1.043, 95% confidence interval [CI] 1.019-1.067, p < 0.001). An Hs-cTnT level of 0.55 ng/L was predictive of prehypertension with a sensitivity of 86% and specificity of 60% (area under the curve = 0.861; 95% CI, 0.787-0.935; p < 0.001).
hs-cTnT may complement other diagnostic biomarkers in predicting prehypertension. Abbrevations: high-sensitivity cardiac troponin T, prehypertension, subclinical myocardial injury.
高敏心肌肌钙蛋白 T（hs-cTNT）是一种重要的、基于实验室的亚临床心肌损伤的非侵入性标志物。高血压前期，可能是高血压的前兆，是一个主要的公共卫生问题。我们的目的是评估血清 hs-cTnT 作为预测高血压前期的标志物的重要性。
共纳入 100 例受试者（45 名女性和 55 名男性），包括 50 例连续的血压在 120/80-139/89mmHg 之间的高血压前期患者和 50 例血压<120/80mmHg 的血压正常患者。计算并比较两组 hs-cTNT 水平。所有患者均进行超声心动图检查。
高血压前期组 hs-cTnT 水平显著升高（p<0.001），与高血压前期呈正相关（r=0.625，p<0.001）。hs-cTnT 是高血压前期的独立预测因子（比值比=1.043，95%置信区间[CI]1.019-1.067，p<0.001）。hs-cTnT 水平为 0.55ng/L 时，对高血压前期的预测具有敏感性为 86%，特异性为 60%（曲线下面积=0.861；95%CI，0.787-0.935；p<0.001）。
hs-cTnT 可能补充其他诊断生物标志物来预测高血压前期。缩写：高敏心肌肌钙蛋白 T，高血压前期，亚临床心肌损伤。
