Veterans Administration Hospital, Orlando, Florida (Dr Banks); Internal Medicine Clinic, Wilford Hall Ambulatory Surgical Clinic, Lackland AFB, Texas (Dr Bolduc); Orlando Veterans Administration Medical Center, Orlando, Florida (Dr Ali); and Pulmonary/Critical Care Service, Department of Medicine San Antonio Military Medical Center, JBSA, Fort Sam Houston, Texas (Dr Morris).
J Occup Environ Med. 2018 Jan;60(1):90-96. doi: 10.1097/JOM.0000000000001176.
We identified cases of constrictive bronchiolitis (CB), an inflammatory injury obliterating the small airways, in adults caused by inhalational exposure to determine an appropriate case definition.
We performed a systematic review with meta-analysis for these cases from 1990 to 2017. Publications were included if there was 1) inhalational exposure; 2) respiratory symptoms/signs; 3) pulmonary function test results; and 4) computerized tomographic chest imaging. Many had a lung biopsy.
Two hundred seventy-four articles were retrieved; 22 manuscripts comprising 102 cases were included. Diagnostic criteria from cases associated with military deployment to southwest Asia were statistically different from criteria of other etiologies.
In three cases, the scan was consistent with CB, the biopsy nondiagnostic, yet the diagnosis was made. CB associated with military deployment presented with diagnostic features statistically different from features in the other cases.
我们确定了成人因吸入暴露而导致的小气道炎症性损伤致缩窄性细支气管炎（CB）的病例，以确定合适的病例定义。
我们对 1990 年至 2017 年的这些病例进行了系统评价和荟萃分析。如果存在 1）吸入暴露；2）呼吸症状/体征；3）肺功能检查结果；和 4）胸部计算机断层扫描成像，则将出版物包括在内。许多患者进行了肺活检。
检索到 274 篇文章；22 篇手稿包含 102 例。与军事部署到西南亚有关的病例的诊断标准与其他病因的标准在统计学上不同。
在三个病例中，扫描结果与 CB 一致，活检无诊断性，但仍做出了诊断。与军事部署相关的 CB 表现出与其他病例在统计学上不同的诊断特征。
