Wertheimer Christian, Haritoglou Christos, Laubichler Peter, Wolf Armin, Kaessmann Kathrin, Schumann Ricarda G, Priglinger Siegfried, Mayer Wolfgang J
Department of Ophthalmology, Ludwig-Maximilians-University Munich, Munich, Germany.
Ophthalmologica. 2018;239(1):11-18. doi: 10.1159/000480406. Epub 2017 Sep 28.
To investigate the impact of spectral domain optical coherence tomography (SD-OCT) morphological predictive markers on visual acuity and outcome using ocriplasmin for macular hole and vitreomacular traction syndrome.
A series of 40 patients in a retrospective study received intravitreal ocriplasmin. The primary endpoint was defined as morphological resolution of vitreomacular traction or closure of a macular hole. We analyzed the impact of pre- and postinjection SD-OCT findings on the outcome and visual acuity.
Thirteen of the 40 patients benefited from treatment. Statistical correlation between baseline characteristics and outcome revealed that higher foveal thickness (p = 0.018) and nontractional epiretinal membranes (p = 0.05) resulted in a worse outcome. In treatment success best corrected visual acuity gained was 9 (SD 12) letters and in failure 1 (SD 9) letter. We could not observe an influence of preinjection SD-OCT findings and other factors on visual outcome.
We could confirm the therapeutic effect of ocriplasmin injections. SD-OCT morphological factors that influence treatment success and visual acuity were determined.
研究频域光学相干断层扫描（SD-OCT）形态学预测指标对玻璃体内注射奥克纤溶酶治疗黄斑裂孔和玻璃体黄斑牵拉综合征时视力及治疗效果的影响。
在一项回顾性研究中，40例患者接受了玻璃体内奥克纤溶酶注射。主要终点定义为玻璃体黄斑牵拉的形态学缓解或黄斑裂孔闭合。我们分析了注射前和注射后SD-OCT检查结果对治疗效果和视力的影响。
40例患者中有13例从治疗中获益。基线特征与治疗效果之间的统计学相关性显示，较高的黄斑中心凹厚度（p = 0.018）和非牵拉性视网膜前膜（p = 0.05）导致治疗效果较差。治疗成功组最佳矫正视力提高了9（标准差12）个字母，治疗失败组提高了1（标准差9）个字母。我们未观察到注射前SD-OCT检查结果及其他因素对视力转归的影响。
我们证实了奥克纤溶酶注射的治疗效果。确定了影响治疗成功和视力的SD-OCT形态学因素。
