Bioavailability of indenolol by nasal and intravenous routes.

The blood levels of indenolol were determined in rats following nasal and intravenous administration of 5 mg/kg body weight of the drug. The results indicate that the peak drug levels reach within 10 minutes of nasal administration. The areas under the curve for nasal and intravenous routes were found to be 65.67 (ng x hr)/ml and 65.32 (ng x hr)/ml respectively. The results suggest that nasal route may be of practical value for the administration of indenolol.