Hida Tetsuya, Minami Mitsuyoshi, Kubo Yoshiaki
Division of Dermatology, Matsuyama Red Cross Hospital.
Department of Dermatology, Tokushima University Graduate School of Medical Science.
J Med Invest. 2017;64(3.4):308-310. doi: 10.2152/jmi.64.308.
Calcinosis cutis can be classified into four subtypes: dystrophic, metastatic, idiopathic, and iatrogenic. Of these subtypes, dystrophic calcinosis (DC) is the most common, and is most frequently associated with connective tissue disease, particularly dermatomyositis and systemic sclerosis, and less commonly with systemic lupus erythematosus. However, DC associated with rheumatoid arthritis (RA) is extremely rare. In this paper, we present a Japanese woman with RA, who suffered from bilateral leg ulcers secondary to DC. To the best of our knowledge, only two cases of DC associated with RA have been reported to date. Similar to this case, the DC lesions were observed in the extremities, including the buttocks in the other two cases. Although the ulcers on her left leg were gradually epithelialized after one year, they may easily recur due to whitish abnormal underlying tissues, and a large ulcer remains on her right leg. Thus, it is important for physicians to identify DC when encountering non-healing leg ulcers associated with connective tissue diseases. J. Med. Invest. 64: 308-310, August, 2017.
营养不良性、转移性、特发性和医源性。在这些亚型中，营养不良性钙化症（DC）最为常见，最常与结缔组织病相关，尤其是皮肌炎和系统性硬化症，较少与系统性红斑狼疮相关。然而，与类风湿关节炎（RA）相关的DC极为罕见。在本文中，我们报告了一名患有RA的日本女性，她因DC继发双侧腿部溃疡。据我们所知，迄今为止仅报道了两例与RA相关的DC病例。与本病例相似，另外两例的DC病变也出现在四肢，包括臀部。尽管她左腿的溃疡在一年后逐渐上皮化，但由于下方组织呈白色异常，溃疡可能很容易复发，并且她的右腿仍有一个大溃疡。因此，医生在遇到与结缔组织病相关的不愈合腿部溃疡时识别出DC很重要。《医学调查杂志》64: 308 - 310, 2017年8月。
