Kulsoom Bibi, Shamsi Tahir Sultan, Ahmed Nikhat, Hasnain Syed Nazrul
NIBD Karachi, Pakistan. Alfaisal University, Riyadh, Saudi Arabia.
Institute of Health Sciences and Blood Diseases Centre, Karachi.
J Pak Med Assoc. 2017 Oct;67(10):1580-1587.
Acute myeloid leukaemia (AML) is a group of haematological malignant disorders. Although not a new disease, many studies have been conducted to explore AML etiology, pathogenesis and prognosis at molecular level over the past two decades. A meticulous and continuous review of the available literature is still required to contemplate currently discovered information. We searched Google Scholar and PubMed by using different key word such as: updates in diagnostic criteria of AML, WHO classification of AML, new prognostic factors and risk stratification of AML. Mostly articles are referred from international sources published during last five years. Some older articles were only used when pivotal information required could not be surpassed by newer articles. Initially 50 relevant articles were included which were subsequently reduced to 36 by excluding articles with similar information. In this review an attempt is made to approach the subject in the light of currently available literature.
急性髓系白血病（AML）是一组血液系统恶性疾病。尽管它并非新疾病，但在过去二十年里，已经开展了许多研究以在分子水平上探索AML的病因、发病机制和预后。仍需要对现有文献进行细致且持续的回顾，以便思考当前已发现的信息。我们通过使用不同关键词在谷歌学术和PubMed上进行搜索，如：AML诊断标准的更新、WHO对AML的分类、AML的新预后因素和风险分层。大多数文章引用自过去五年发表的国际文献来源。仅在需要的关键信息无法被新文章超越时才使用一些较旧的文章。最初纳入了50篇相关文章，随后通过排除具有相似信息的文章将数量减少至36篇。在本综述中，我们尝试根据当前可得的文献来探讨该主题。
