Ehira T, Romanus M
First Department of Surgery, St. Marianna University School of Medicine, Kawasaki, Japan.
Acta Chir Scand. 1988 Jan;154(1):13-7.
Indomethacin can reduce the microvascular permeability induced by repeated ischemia. In this investigation the influence of histamine H1 and H2 receptor blockers was studied for comparison with indomethacin. Application of 60 mmHg pressure to the hamster cheek pouch for 5 min was repeated eight times, with 10-min restitution intervals. Altered permeability was evaluated with use of FITC-dextran and intravital microscopy. Progressive efflux of FITC-dextran was observed in the control group. When either diphenhydramine or indomethacin was used alone, a few spots of extravasated dye were seen. Combination of diphenhydramine with either indomethacin or cimetidine reduced the extravasation. Furthermore, the spots appeared significantly later than in the controls, and some faded. Increase in the efflux of macromolecules due to repeated ischemia seems to be mediated via H1 and H2 receptors in conjunction with other receptors and/or amines e.g. prostaglandins.
吲哚美辛可降低反复缺血诱导的微血管通透性。在本研究中，研究了组胺H1和H2受体阻滞剂的影响，以便与吲哚美辛进行比较。对仓鼠颊囊施加60 mmHg压力5分钟，重复8次，恢复间隔为10分钟。使用异硫氰酸荧光素标记的葡聚糖和活体显微镜评估通透性的改变。在对照组中观察到异硫氰酸荧光素标记的葡聚糖逐渐外渗。当单独使用苯海拉明或吲哚美辛时，可见少量染料外渗斑点。苯海拉明与吲哚美辛或西咪替丁联合使用可减少外渗。此外，这些斑点出现的时间明显晚于对照组，并且有些褪色。反复缺血导致的大分子外渗增加似乎是通过H1和H2受体与其他受体和/或胺（如前列腺素）共同介导的。
