TSLP受体对小鼠屋尘螨诱导的变应性鼻炎并非必不可少。
TSLP receptor is not essential for house dust mite-induced allergic rhinitis in mice.
作者信息
Nakanishi Wakako, Hiraishi Yoshihisa, Yamaguchi Sachiko, Takamori Ayako, Morita Hideaki, Matsumoto Kenji, Saito Hirohisa, Sudo Katsuko, Yamasoba Tatsuya, Nakae Susumu
机构信息
Laboratory of Systems Biology, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
出版信息
Biochem Biophys Rep. 2016 Jun 6;7:119-123. doi: 10.1016/j.bbrep.2016.06.003. eCollection 2016 Sep.
TSLP induces Th2 cytokine production by Th2 cells and various other types of cells, thereby contributing to Th2-type immune responses and development of allergic disorders. We found that house dust mite (HDM) extract induced TSLP production by nasal epithelial cells, suggesting that TSLP may be involved in development of HDM-induced allergic rhinitis (AR). To investigate that possibility in greater detail, wild-type and TSLP receptor-deficient (TSLPR) mice on the C57BL/6J background were repeatedly treated intranasally with HDM extract. The frequency of sneezing, numbers of eosinophils and goblet cells, thickness of submucosal layers, serum levels of total IgE and HDM-specific IgG1, and levels of IL-4, IL-5 and IL-13 in the culture supernatants of HDM-stimulated LN cells were comparable in the two mouse strains. Those findings indicate that, in mice, TSLPR is not crucial for development of HDM-induced AR.
胸腺基质淋巴细胞生成素（TSLP）可诱导Th2细胞及其他多种类型细胞产生Th2细胞因子，从而促进Th2型免疫反应及过敏性疾病的发展。我们发现，屋尘螨（HDM）提取物可诱导鼻上皮细胞产生TSLP，这表明TSLP可能参与HDM诱导的过敏性鼻炎（AR）的发病过程。为更详细地研究这种可能性，我们对C57BL/6J背景的野生型和TSLP受体缺陷（TSLPR）小鼠经鼻反复给予HDM提取物。在这两种小鼠品系中，打喷嚏的频率、嗜酸性粒细胞和杯状细胞的数量、黏膜下层的厚度、血清总IgE和HDM特异性IgG1水平以及HDM刺激的淋巴结细胞培养上清液中IL-4、IL-5和IL-13的水平相当。这些发现表明，在小鼠中，TSLPR对HDM诱导的AR的发病并非至关重要。
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