膳食鱼油对小鼠睾酮水平及睾丸间质中含二十碳五烯酸的磷脂酰胆碱分布的影响。
Effect of dietary fish oil on mouse testosterone level and the distribution of eicosapentaenoic acid-containing phosphatidylcholine in testicular interstitium.
作者信息
Zaima Nobuhiro, Kinoshita Saori, Hieda Nao, Kugo Hirona, Narisawa Kaori, Yamamoto Ayami, Yanagimoto Kenichi, Moriyama Tatsuya
机构信息
Department of Applied Biological Chemistry, Graduate School of Agricultural Science, Kindai University, 204-3327 Nakamachi, Nara City, Nara 631-8505, Japan.
Human Life Science R&D Center, Nippon Suisan Kaisha, Ltd., Tokyo, Japan.
出版信息
Biochem Biophys Rep. 2016 Jun 30;7:259-265. doi: 10.1016/j.bbrep.2016.06.014. eCollection 2016 Sep.
Low levels of serum testosterone are characteristically associated with diabetes, coronary atherosclerosis, obstructive sleep apnea, rheumatoid arthritis, and chronic obstructive pulmonary disease. Testosterone replacement therapy is effective against many of these disorders, indicating the importance of maintaining a healthy testosterone level. In this study, we investigated the effects of fish oil on murine testosterone metabolism and analyzed the dynamics of relevant lipids in testes by matrix-assisted laser desorption ionization mass spectrometry imaging. Testosterone was upregulated in mice that received fish oil. In the testicular interstitium, eicosapentaenoic acid-containing phosphatidylcholine was distributed characteristically. These data suggest that eicosapentaenoic acid is involved in testosterone metabolism.
低水平的血清睾酮通常与糖尿病、冠状动脉粥样硬化、阻塞性睡眠呼吸暂停、类风湿性关节炎和慢性阻塞性肺疾病相关。睾酮替代疗法对其中许多疾病有效，这表明维持健康的睾酮水平很重要。在本研究中，我们研究了鱼油对小鼠睾酮代谢的影响，并通过基质辅助激光解吸电离质谱成像分析了睾丸中相关脂质的动态变化。接受鱼油的小鼠体内睾酮水平上调。在睾丸间质中，含二十碳五烯酸的磷脂酰胆碱呈特征性分布。这些数据表明二十碳五烯酸参与了睾酮代谢。
Zotero 插件