一些杀锥虫双脒的α-肾上腺素能受体阻断特性
Alpha-adrenoceptor-blocking properties of some trypanocidal diamidines.
作者信息
Steinmann U, Estler C J, Dann O
机构信息
Institute of Pharmacology and Toxicology, University of Erlangen-Nürnberg, F.R.G.
出版信息
Arch Int Pharmacodyn Ther. 1987 Dec;290(2):207-14.
PMID:2895613
Abstract
A series of trypanocidal diamidines and diimidazolines known to cause severe hypotension were tested for their alpha-adrenoceptor blocking properties in vitro. At the postsynaptic alpha 1-receptor of the guinea-pig aorta in vitro all compounds at doses of 0.5 to 50 mumol/l showed weak antagonistic effects against noradrenaline. Similar results were obtained at the presynaptic alpha 2-receptor of the rat vas deferens.
摘要
对一系列已知会导致严重低血压的杀锥虫双脒和双咪唑啉进行了体外α-肾上腺素能受体阻断特性测试。在体外豚鼠主动脉的突触后α1受体处，所有化合物在0.5至50μmol / l的剂量下对去甲肾上腺素均表现出微弱的拮抗作用。在大鼠输精管的突触前α2受体处也得到了类似结果。
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